Fig. 4. Small molecule glycomimetics down-regulate c-Met/Notch3/HES1 signalling in β-GP-induced human VSMCs. (A) c-Met^Tyr1349 phosphorylation was significantly increased after treatment with β-GP for 21 days which was significantly decreased by C2, C4, crizotinib and DAPT. (B, C) C2 and DAPT significantly decreased Notch3 (B) and HES-1 (C) protein expression in VSMCs treated with β-GP for 21 days. Results are mean ± SEM; n = 6. *P<0.05, **P<0.01, ***P<0.001. β-GP, β-glycerophosphate; ns, non-significant.